Table 2.
Effect of treatments on blood glucose (PBG) and area under the curve (AUC) after glucose loading (4 g/kg) in non-diabetic rats (NDRs) and STZ-diabetic rats (SDRs)
| Group | PBG (mmol/L) | % Reduction of PBG | AUC (mmol/L) | % Reduction of AUC |
|---|---|---|---|---|
| Non-diabetic rats |
||||
| NC (vehicle) |
8.9 ± 0.34 |
|
14.4 ± 0.32 |
|
| ACAR (10 mg/kg) |
6.5 ± 0.32* |
26.97 |
11.2 ± 0.44* |
22.22 |
| ME (1 g/kg) |
7.4 ± 0.31 |
16.85 |
12.4 ± 0.48* |
13.89 |
| NBF (1 g/kg) |
7.15 ± 0.18 |
19.66 |
12.08 ± 0.28* |
16.11 |
| SFI (1 g/kg) |
6.20 ± 0.15* |
30.34 |
11.04 ± 0.09* |
23.33 |
| Diabetic rats |
||||
| DC (vehicle) |
21.92 ± 0.8 |
|
39.93 ± 1.75 |
|
| ACAR (10 mg/kg) |
17.37 ± 0.66* |
20.76 |
27.47 ± 0.9* |
31.20 |
| ME (1 g/kg) |
22.05 ± 0.53 |
- |
40.08 ± 0.74 |
- |
| NBF (1 g/kg) |
21.33 ± 1.22 |
2.69 |
37.05 ± 1.6 |
7.21 |
| SFI (1 g/kg) | 19.85 ± 1.42 | 9.44 | 34.58 ± 2.34 | 13.40 |
Values are the mean ± SEM, n = 6, *P < 0.05 vs. control. NC: Normal control, DC: Diabetic control, ACAR: Acarbose, ME: Methanol extract, NBF: n-Butanol fraction, SFI: Sub-fraction 1.