Table 3.
Effect of treatments on peak blood glucose (PBG) and area under the curve (AUC) after sucrose loading (4 g/kg) in non-diabetic rats (NDRs) and STZ-diabetic rats (SDRs)
| Group | PBG (mmol/L) | % Reduction of PBG | AUC (mmol/L) | % Reduction of AUC |
|---|---|---|---|---|
| Non-diabetic rats |
||||
| NC (vehicle) |
7.35 ± 0.41 |
|
13.04 ± 0.54 |
|
| ACAR (10 mg/kg) |
5.53 ± 0.14* |
24.76 |
10.22 ± 0.19* |
21.63 |
| ME (1 g/kg) |
6.30 ± 0.10 |
14.29 |
11.46 ± 0.18 |
12.12 |
| NBF (1 g/kg) |
6.52 ± 0.18 |
11.29 |
11.65 ± 0.28 |
10.66 |
| SFI (1 g/kg) |
6.08 ± 0.14 |
17.28 |
11.01 ± 0.20* |
15.57 |
| Diabetic rats |
||||
| DC (vehicle) |
24.14 ± 1.14 |
|
43.71 ± 1.10 |
|
| ACAR (10 mg/kg) |
18.5 ± 0.96* |
23.36 |
29.92 ± 0.78* |
31.55 |
| ME (1 g/kg) |
21.5 ± 1.10 |
10.94 |
40.97 ± 1.66 |
6.27 |
| NBF (1 g/kg) |
20.53 ± 0.9 |
15.08 |
37.49 ± 1.45* |
14.23 |
| SFI (1 g/kg) | 22.58 ± 1.45 | 6.46 | 38.27 ± 1.68* | 12.46 |
Values are the mean ± SEM, n = 6, *P < 0.05 vs. control. NC: Normal control, DC: Diabetic control, ACAR: Acarbose, ME: Methanol extract, NBF: n-Butanol fraction, SFI: Sub-fraction 1.