Table 4.
Effect of treatments on peak blood glucose (PBG) and area under the curve (AUC) after starch loading (4 g/kg) in non-diabetic rats (NDRs) and STZ-diabetic rats (SDRs)
| Group | PBG (mmol/L) | % Reduction of PBG | AUC (mmol/L) | % Reduction of AUC |
|---|---|---|---|---|
| Non-diabetic rats |
||||
| NC (vehicle) |
6.12 ± 0.10 |
|
11.22 ± 0.17 |
|
| ACAR (10 mg/kg) |
4.43 ± 0.11* |
27.61 |
9.10 ± 0.19* |
18.89 |
| ME (1 g/kg) |
5.78 ± 0.39 |
5.56 |
10.37 ± 0.50 |
7.58 |
| NBF (1 g/kg) |
5.18 ± 0.08* |
15.36 |
9.61 ± 0.08 |
14.35 |
| SFI (1 g/kg) |
5.97 ± 0.05 |
2.45 |
10.58 ± 0.15 |
5.70 |
| Diabetic rats |
||||
| DC (vehicle) |
22.5 ± 1.02 |
|
41.2 ± 1.74 |
|
| ACAR (10 mg/kg) |
18.7 ± 1.95 |
16.89 |
26.1 ± 2.8* |
36.65 |
| ME (1 g/kg) |
22.6 ± 1.03 |
- |
43.9 ± 2.99 |
- |
| NBF (1 g/kg) |
21.1 ± 1.38 |
6.22 |
35.6 ± 2.32 |
13.59 |
| SFI (1 g/kg) | 19.1 ± 1.00 | 15.11 | 33.5 ± 1.5 | 18.69 |
Values are the mean ± SEM, n = 6, *P < 0.05 vs. control. NC: Normal control, DC: Diabetic control, ACAR: Acarbose, ME: Methanol extract, NBF: n-Butanol fraction, SFI: Sub-fraction 1.