Figure 7.

Odorant receptors are trafficked normally to the cilia of olfactory sensory neurons in tubby mice. Localization of the odorant receptor mOR28 in the olfactory sensory cilia appears indistinguishable between WT and tubby mutant. (A) mOR28 (green) double labeled with α-acetylated tubulin (red) which highlight the ciliary axoneme. In both WT and mutant tissues, mOR28 appear localized to the cilia layer with weaker signal appearing in the neuronal soma in both genotypes. (B) mOR28 (green) double labeled with rootletin (red). In both WT and mutant tissues, mOR28 is localized distal to rootletin, as would be expected for a ciliary localization.