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. Author manuscript; available in PMC: 2013 Mar 16.

Published in final edited form as: J Cereb Blood Flow Metab. 2009 Jun 17;29(9):1568–1578. doi: 10.1038/jcbfm.2009.79

Fig.4 — Vascular space of control and EAE mice after induction with PLP and CFA.

(A) In the striatum and thalamus, the vascular space was slightly increased in the EAE mouse 11 days after PLP treatment (d11) in the area under the dorsal 3^rd ventricle (d3V) (arrows), and was significantly increased at d29, compared with the controls.

(B) The blood vessels beneath the median eminence (ME) also showed a similar pattern in EAE mice. There is no significant difference between control and EAE mice in the vascular space in most of the brain regions, as shown in the arcuate nucleus (Arc). There was no BBB leakage seen in EAE mice within this perfusion time frame but the diffusion of FITC-albumin can be seen in CVOs, such as the ME (scale bar = 200 μm).

Fig.4C. Disappearance of ¹²⁵I-IL15 and ¹³¹I-albumin from blood after iv bolus injection. EAE was associated with altered kinetics and a shortened half-life for both substances.

Fig.4 — Vascular space of control and EAE mice after induction with PLP and CFA.

(A) In the striatum and thalamus, the vascular space was slightly increased in the EAE mouse 11 days after PLP treatment (d11) in the area under the dorsal 3^rd ventricle (d3V) (arrows), and was significantly increased at d29, compared with the controls.

(B) The blood vessels beneath the median eminence (ME) also showed a similar pattern in EAE mice. There is no significant difference between control and EAE mice in the vascular space in most of the brain regions, as shown in the arcuate nucleus (Arc). There was no BBB leakage seen in EAE mice within this perfusion time frame but the diffusion of FITC-albumin can be seen in CVOs, such as the ME (scale bar = 200 μm).

Fig.4C. Disappearance of ¹²⁵I-IL15 and ¹³¹I-albumin from blood after iv bolus injection. EAE was associated with altered kinetics and a shortened half-life for both substances.