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. 2013 Feb 21;13:18. doi: 10.1186/1475-2867-13-18

Figure 3.

Figure 3

The role of demethylating agent and autophagy inhibitor on autophagy. A) Representative of Western blot of LC3-I and LC3-II protein expression. Demethylating agent 5-Aza upregulated LC3-II and downregulated LC3-I levels in a dose-dependent manner. B) Relative LC3-II/LC3-I ratio in A). *p < 0.01, **p < 0.001 vs. 0 μmol/L of 5-Aza group. N = 5. C) Representative of Western blot of LC3-I and LC3-II protein expression under treatment of 5-Aza with or without 3-MA treatment. D) Relative LC3-II/LC3-I ratio in C). *p < 0.01, **p < 0.001 vs. 0 μmol/L of 5-Aza group. N = 5.