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. 2013 Mar 8;13:106. doi: 10.1186/1471-2407-13-106

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Copyright ©2013 Yasui et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Disruption of the BBB in the brain of a C6-bearing rat. (A) Representative photographs of the dorsal surface (I), ventral surface (II), coronal slice (III) and sagittal slice (IV) of control brain (a) and C6-bearing brain (b) after perfusion with Evans blue dye. (B) Representative T1-weighted MR images obtained before and after Gd-[DTPA] injection. White lines show the region with high signal intensity, indicating the BBB-disrupted region. (C) Quantitative data for Gd-[DTPA]-based CE-MRI. Relative MRI signal intensities are expressed as ratios relative to the normal brain region.