Figure 4.
Effects of the combination of doranidazole and X-irradiation on tumor growth in C6 glioma. When the tumor reached a size of 50–100 mm3, rats were treated with doranidazole (200 mg/kg) and/or X-irradiation (6 Gy). (A) Typical T2-weighted MR images of a C6-bearing brain before and after each treatment. (B) The quantitative data for suppression of tumor growth by doranidazole administration and/or X-irradiation. The sizes of tumors were estimated using T2-weighted MRI before treatment and at 7 days after treatment. Data are expressed as the mean ± S.E. for 5–8 different tumors. *: P < 0.05, **: P < 0.01.