Table 4.
Comparison of anti-protozoal activity (IC50) and cytotoxicity (CC50) of alkaloids from Annickia kummeriae with standard drugs
| Compound | IC50 cpd IC50 CQ | IC50 cpd IC50 Art | IC50 cpd IC50 Mel | IC50 cpd IC50 Milt | CC50 cpd CC50 Pdx |
|---|---|---|---|---|---|
| Lysicamine (1) |
38.1 |
1,200.0 |
1,850.0 |
23.6 |
177.8 |
| Trivalvone (2) |
25.4 |
800.0 |
7,150.0 |
26.4 |
5,033.3 |
| Palmatine (3) |
1.3 |
40.0 |
1,600.0 |
70.9 |
>10,000 |
| Jatrorrhizine (4) |
3.8 |
120 |
2,100.0 |
185.5 |
>10,000 |
| Jatrorrhizine (4) + columbamine (5) (1.2:1.0) |
2.2 |
69.0 |
2,000.0 |
119.1 |
5,577.8 |
| Palmatine (3) + (−)-tetrahydropalmatine (6) (1.1:1.0) | 1.6 | 49.0 | 2,150.0 | 63.64 | 6,855.6 |
Cpd isolated compound, CQ chloroquine, Art artemisinin, Mel melarsoprol, Pdx podophyllotoxin.