Table 5.
Univariate and multivariate analysis of prognostic factors for PFS
| |
Univariate |
Multivariate |
||||
|---|---|---|---|---|---|---|
| Variable | HR | 95% CI | P | HR | 95% CI | P |
|
KPS |
|
|
|
|
|
|
| ≥ 80 vs. 70 |
0.4 |
0.16-0.99 |
0.048 |
0.29 |
0.09-1.00 |
0.049 |
|
RPA class |
|
|
|
|
|
|
| Class III vs. Class IV and V |
0.34 |
0.10-1.11 |
0.075 |
|
|
NS |
|
Adjuvant TMZ |
|
|
|
|
|
|
| ≥3 cycles vs. < 3 cycles |
0.84 |
0.72-0.982 |
0.028 |
0.79 |
0.65-0.96 |
0.02 |
|
Extent of resection |
|
|
|
|
|
|
| GTR vs. biopsy or STR |
0.54 |
0.15-1.91 |
0.339 |
|
|
NS |
|
Time interval between the date of surgery and start of RT |
|
|
|
|
|
|
| ≥ 6 weeks vs. < 6 weeks | 1.08 | 0.45-2.59 | 0.867 | NS | ||
Abbreviations: PFS: progression free survival; HR: hazard ration; CI: confidence interval; KPS: Karnofsky performance status; RPA: recursive partitioning analysis; TMZ: Temozolomide; GTR: gross total resection; STR: subtotal resection; RT: radiation therapy.