Table 6.
Univariate and multivariate analysis of prognostic factors for OS
| |
Univariate |
Multivariate |
||||
|---|---|---|---|---|---|---|
| Variable | HR | 95% CI | P | HR | 95% CI | P |
|
KPS |
|
|
|
|
|
|
| ≥ 80 vs. 70 |
1.32 |
0.50-3.46 |
0.573 |
|
|
NS |
|
RPA class |
|
|
|
|
|
|
| Class III vs. Class IV and V |
2.51 |
0.56-11.20 |
0.228 |
|
|
NS |
|
Adjuvant TMZ |
|
|
|
|
|
|
| ≥3 cycles vs. < 3 cycles |
0.79 |
0.64-0.97 |
0.024 |
0.83 |
0.69-0.99 |
0.042 |
|
Extent of resection |
|
|
|
|
|
|
| GTR vs. biopsy or STR |
1.99 |
0.45-8.86 |
0.368 |
|
|
NS |
|
Time interval between the date of surgery and start of RT |
|
|
|
|
|
|
| ≥ 6 weeks vs. < 6 weeks | 3.18 | 1.20-8.40 | 0.02 | 2.94 | 1.06-8.18 | 0.039 |
Abbreviations: OS: overall survival; HR: hazard ration; CI: confidence interval; KPS: Karnofsky performance status; RPA: recursive partitioning analysis; TMZ: Temozolomide; GTR: gross total resection; STR: subtotal resection; RT: radiation therapy.