Table 2.
Tumorigenicity and metastasis of the two cell lines following orthotopic transplantation in nude mice
| Round No. | Tumor source | Incidence of tumorigenicity (a/b) † | Enlarged lymph nodes near the ventral aorta | Pulmonary metastasis (a/b) † | Hemorrhagic ascites (a/b) † | Cachexy (a/b) † |
|---|---|---|---|---|---|---|
|
MRCC |
|
|
|
|
|
|
| 1 |
Primary |
5/5 |
No |
0/5 |
0/5 |
0/5 |
| 2 |
Primary |
5/5 |
Yes |
4/5 |
4/5 |
2/5 |
| 3 |
Metastasis |
5/5 |
Yes |
4/5 |
4/5 |
3/5 |
| 4 |
Metastasis |
5/5 |
Yes |
4/5 |
2/5 |
3/5 |
| 5 |
Metastasis |
5/5 |
Yes |
5/5 |
3/5 |
5/5 |
| 6 |
Metastasis |
5/5 |
Yes |
5/5 |
3/5 |
5/5 |
|
NRCC |
|
|
|
|
|
|
| 1 |
Primary |
4/5 |
No |
0/5 |
0/5 |
0/5 |
| 2 |
Primary |
5/5 |
No |
0/5 |
0/5 |
0/5 |
| 3 | Primary | 5/5 | No | 0/5 | 0/5 | 0/5 |
† a, the number of mice with the event of interest (tumorigenicity, metastasis, hemorrhagic ascites or cachexy);
b, total number of mice orthotopically transplanted with the minced tumor masses.