Table 5.
Gene ontology analysis
| Category | GO ID | Level | Term | Count | % | p value | Genes (gene symbols) |
|---|---|---|---|---|---|---|---|
| GOTERM_BP_ALL |
GO:0009987 |
02 |
cellular process |
47 |
55,3 |
0,035 |
ACAN, ACOT1, ACOT7, ANGPTL4, APBA1, ARID2, ARNTL, ASS1, ATF3, ATP1B4, ATP12A,BCL2A1D, BEX1, CAMK2G, CBR1, CHRNG, COL24A1, CSGALNACT1, CTGF, DCXR, DLG4, DUSP3, EXO1, GSTA5, HAP1, HDAC5, HEY2, HIPK2, HMGCS2, HSPA1A, HSPA1B, HNRPLL, IRX3, LOC360228, LOC501189, NGFR, NNAT, NTSR2, PCK2, SNED1, SPTBN2, ST8SIA4, STRBP, TAF13, TGM1, TYMS, UCHL1 |
| GOTERM_BP_ALL |
GO:0009266 |
04 |
response to temperature stimulus |
5 |
5,9 |
0,013 |
CIRBP, HSPA1A, HSPA1B, IL18, NGFR |
| GOTERM_BP_ALL |
GO:0042180 |
04 |
cellular ketone metabolic process |
9 |
10,6 |
0,004 |
ACOT1, ACOT7, ARID2, ASS1, ATF3, CBR1, CSGALNACT1, HNRPLL, PCK2 |
| GOTERM_BP_ALL |
GO:0006082 |
04 |
organic acid metabolic process |
8 |
9,4 |
0,014 |
ACOT1, ACOT7, ARID2, ASS1, ATF3, CSGALNACT1, HNRPLL, PCK2 |
| GOTERM_BP_ALL |
GO:0019752 |
05 |
carboxylic acid metabolic process |
8 |
9,4 |
0,014 |
ACOT1, ACOT7, ARID2, ASS1, ATF3, CSGALNACT1, HNRPLL, PCK2 |
| GOTERM_BP_ALL |
GO:0043436 |
05 |
oxoacid metabolic process |
8 |
9,4 |
0,014 |
ACOT1, ACOT7, ARID2, ASS1, ATF3, CSGALNACT1, HNRPLL, PCK2 |
| GOTERM_BP_ALL |
GO:0034637 |
05 |
cellular carbohydrate biosynthetic process |
3 |
3,5 |
0,039 |
ATF3, CSGALNACT1, PCK2 |
| GOTERM_BP_ALL |
GO:0051346 |
06 |
negative regulation of hydrolase activity |
4 |
4,7 |
0,023 |
ANGPTL4, BCL2A1D, HSPA1A, HSPA1B, |
| GOTERM_BP_ALL |
GO:0008284 |
06 |
positive regulation of cell proliferation |
6 |
7,1 |
0,039 |
ATF3, BEX1, HEY2, HIPK2, IL18, NGFR |
| GOTERM_BP_ALL |
GO:0048489 |
07 |
synaptic vesicle transport |
3 |
3,5 |
0,017 |
APBA1, DLG4, SPTBN2 |
| GOTERM_BP_ALL |
GO:0032502 |
02 |
developmental process |
25 |
29,4 |
0,001 |
ACAN, ANGPTL4, APBA1, ASS1, ATF3, BCL2A1D, BEX1, CBR1, CTGF, DLG4, EXO1, HAP1, HEY2, HIPK2, IL18, IRX3, KLK14, LOC360228, NGFR, NNAT, NRG2, ODZ4, STRBP, TGM1, UCHL1 |
| GOTERM_BP_ALL |
GO:0048869 |
03 |
cellular developmental process |
15 |
17,6 |
0,012 |
ACAN, ANGPTL4, ATF3, BCL2A1D, BEX1, CTGF, DLG4, HEY2, IRX3, LOC360228, NGFR, NNAT, STRBP, TGM1, UCHL1 |
| GOTERM_BP_ALL |
GO:0007275 |
03 |
multicellular organismal development |
23 |
27,1 |
0,001 |
ACAN, ANGPTL4, APBA1, ASS1, BCL2A1D, BEX1, CBR1, CTGF, DLG4, EXO1,HEY2, HAP1, HIPK2, IL18, IRX3, KLK14, NGFR, NNAT, NRG2, ODZ4, STRBP, TGM1, UCHL1 |
| GOTERM_BP_ALL |
GO:0048856 |
03 |
anatomical structure development |
19 |
22,3 |
0,013 |
ACAN, ANGPTL4, ASS1, BCL2A1D, BEX1, CBR1, CTGF, DLG4, EXO1, HAP1, HEY2, IL18, IRX3, KLK14, NGFR, NNAT, ODZ4, TGM1, UCHL1 |
| GOTERM_BP_ALL |
GO:0048731 |
04 |
system development |
18 |
21,1 |
0,016 |
ACAN, ANGPTL4, ASS1, BCL2A1D, BEX1, CBR1, CTGF, DLG4, EXO1, HAP1, HEY2, IL18, IRX3, KLK14, NGFR, NNAT, TGM1, UCHL1 |
| GOTERM_BP_ALL |
GO:0030154 |
04 |
cell differentiation |
15 |
17,6 |
0,009 |
ACAN, ANGPTL4 ATF3, BCL2A1D, BEX1, CTGF, DLG4, HEY2, IRX3, LOC360228, NGFR, NNAT, STRBP, TGM1, UCHL1 |
| GOTERM_MF_ALL |
GO:0003824 |
02 |
catalytic activity |
30 |
35,3 |
0,037 |
ACOT1, ACOT7, ARID2, ASS1, ATP1B4, ATP12A ,BDH1, CAMK2G, CBR1, CSGALNACT1, DCXR, DUSP3, EXO1,GCAT, GSTA5, HDAC5, HIPK2, HMGCS2, KLK14, LOC286911, LOC501189, MYO9A, PCK2, PLA2G7, RAB7A, RNASE1, ST8SIA4, TYMS, TGM1, UCHL1 |
| GOTERM_MF_ALL |
GO:0016788 |
04 |
hydrolase activity, acting on ester bonds |
7 |
8,2 |
0,041 |
ACOT1, ACOT7, DUSP3, EXO1, PLA2G7, RNASE1, UCHL1 |
| GOTERM_MF_ALL |
GO:0016790 |
05 |
thiolester hydrolase activity |
3 |
3,5 |
0,047 |
ACOT1, ACOT7, UCHL1 |
| GOTERM_CC_ALL |
GO:0031974 |
02 |
membrane-enclosed lumen |
13 |
14,5 |
0,032 |
ARNTL, ASCL3, ASCL3_PREDICTED, ATF3, BDH1, CIRBP, DUSP3, HIPK2, HMGCS2, NGFR, SPTBN2, SUPT16H, TAF13 |
| GOTERM_CC_ALL |
GO:0044421 |
03 |
extracellular region part |
8 |
9,6 |
0,044 |
ACAN, ANGPTL4, COL24A1, CTGF, LOC286911, LOC360228, IL18, KLK14 |
| GOTERM_CC_ALL |
GO:0031090 |
04 |
organelle membrane |
11 |
12,0 |
0,032 |
ASS1, CAMK2G, CSGALNACT1, BDH1, DLG4, GCAT, GSTA5, HIPK2, HMGCS2, LOC501189, ST8SIA4 |
| GOTERM_CC_ALL |
GO:0043233 |
04 |
organelle lumen |
13 |
15,3 |
0,027 |
ARNTL, ASCL3, ASCL3_PREDICTED, ATF3, BDH1, CIRBP, DUSP3, HIPK2, HMGCS2, NGFR, SPTBN2, SUPT16H, TAF13 |
| GOTERM_CC_ALL |
GO:0070013 |
06 |
intracellular organelle lumen |
13 |
15,3 |
0,021 |
ARNTL, ASCL3, ASCL3_PREDICTED, ATF3, BDH1, CIRBP, DUSP3, HIPK2, HMGCS2, NGFR, SPTBN2, SUPT16H, TAF13 |
| GOTERM_CC_ALL |
GO:0005654 |
06 |
nucleoplasm |
9 |
10,6 |
0,045 |
ARNTL, ASCL3, ASCL3_PREDICTED, CIRBP, DUSP3, HIPK2, NGFR, SUPT16H, TAF13 |
| GOTERM_CC_ALL |
GO:0031981 |
07 |
nuclear lumen |
12 |
14,1 |
0,029 |
ARNTL, ASCL3, ASCL3_PREDICTED, ATF3, CIRBP, DUSP3, HIPK2, NGFR, SPTBN2, SUPT16H, TAF13 |
| GOTERM_CC_ALL | GO:0030139 | 08 | endocytic vesicle | 3 | 3,5 | 0,034 | CAMK2G, DLG4, RAB7A |
Significantly enriched gene ontology (GO) terms in the population of genes with altered expression due to metabolic syndrome. GO analysis determines the biological significance of differentially expressed genes that can be used to determine the functional classification of the genes, the expression of which have been significantly up- or down-regulated. Major functional categories of GO terms were separated by horizontal lines, subcategories are represented by level on gene tree.