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G3139 accumulation and Bcl-2 expression in tumors
Panel A. Tumor accumulation profile of FAM-G3139. Following tail i.v. bolus administration of 5 mg/kg of FAM-G3139 loaded sLPD, LPD, or free FAM-G3139 in tumor-bearing mouse (n=3). Each point represents Mean ± SD of three mice.
Panel B. Immunohistochemical staining of Bcl-2 in tumors. Frozen sections were prepared from tumors after 4 times of 5 mg/kg treatment with free G3139 or sLPD-G3139 and stained with anti-human Bcl-2 antibodies.
