. Author manuscript; available in PMC: 2013 Mar 16.

Published in final edited form as: Mol Pharm. 2011 Mar 23;8(3):709–715. doi: 10.1021/mp100272k

Table 2.

Survival of mice after treatments by sLPD-G3139s

Formulation	Median survival time^a (days)	T/C^a (%)	Increase in lifespan^a (%)	Log-rank p compared to PBS group^a	Log-rank p compared to LPD-G3139 group^a
PBS	28	100	0
Free G3139	31^c	110^c	10^c	0.425

Empty LPD	32	114	14	0.378
Empty sLPD	45^b	161^b	61^b	0.022
LPD-G3139	46^b	164^b	64^b	0.017
sLPD-G3139	56^b ^c	200^b ^c	100^b ^c	0.009	0.012

n=5 for each treatment group

Data show significant difference compared to PBS control group

Data show significant difference compared to LPD-G3139 group