Table 4.
Biological processes and pathways linked to experimentally defined and differentially expressed genes in TIA-depleted HeLa cells
| Categories enriched in | Description | Number of genes | Gene symbol | p-value |
|---|---|---|---|---|
|
Up-regulated genes |
|
|||
|
GO term |
|
|||
| GO:0070555 |
Response to interleukin-1 |
2 |
IL1R1, IRAK2 |
6.21E-04 |
| GO:0045087 |
Innate immune response |
2 |
IL1R1, IRAK2 |
6,88E-03 |
| GO:0007165 |
Signal transduction |
2 |
IL1R1, IRAK2 |
2,88E-02 |
|
KEGG term |
|
|||
| Kegg:04080 |
Neuroactive ligand-receptor interaction |
2 |
CNR1, F2RL2 |
6.88E-03 |
| Kegg:04210 |
Apoptosis |
2 |
IL1R1, IRAK2 |
1.43E-03 |
|
Down-regulated genes |
|
|||
|
GO term |
|
|||
| GO:0032836 |
Glomerular basement membrane development |
2 |
COL4A4, NID1 |
1.09E-02 |
|
KEGG term |
|
|||
| Kegg:04144 |
Endocytosis |
4 |
RAB22A, AP2B1, DAB2, PLD1 |
3.23E-02 |
| Kegg:04142 | Lysosome | 3 | CTSC, AP1S2, LAMP2 | 4.77E-02 |
Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) databases analysis were carried out using GeneCodis3 software.