Table 3.
Performance of signature gene sets: cross prediction matrix showing prediction errors
|
Class comparison |
Signature gene set |
This study |
Berry et al. [[4]] |
Maertzdorf et al. [[6]] |
|||||
|---|---|---|---|---|---|---|---|---|---|
| Study | 116 gene set | Minimal TB-LTBI set | Minimal TB-LTBI-HC set | Robust 10 gene q-PCR set | 86 gene set | 393 gene set | 11 gene set | 5 gene set | |
| TB vs. LTBI |
Berry et al.[4] |
20.1 |
19.4 |
nda |
nd |
12.5 |
11.1 |
13.0 |
16.3 |
| Maertzdorf et al.[5] |
26.5 |
22.5 |
nd |
nd |
19.4 |
24.5 |
22.5 |
21.4 |
|
| Maertzdorf et al.[6] |
19.1 |
16.9 |
nd |
nd |
11.3 |
10.1 |
10.2 |
10.1 |
|
| This study |
11.1 |
11.1 |
nd |
nd |
50.0 |
50.0 |
33.0 |
50.0 |
|
|
average prediction error |
19.2 |
17.5 |
nd |
nd |
23.3 |
23.9 |
19.7 |
24.5 |
|
| TB vs. LTBI vs. HC |
Berry et al.[4] |
27.6 |
nd |
23.9 |
34.9 |
20.1 |
14.1 |
27.3 |
30.4 |
| Maertzdorf et al.[5] |
48.6 |
nd |
50.3 |
52.5 |
47.4 |
48.6 |
50.0 |
41.8 |
|
| Maertzdorf et al.[6] |
25.6 |
nd |
25.6 |
48.9 |
17.8 |
21.3 |
26.2 |
32.8 |
|
| This study |
11.1 |
nd |
14.8 |
14.8 |
66.7 |
74.1 |
74.1 |
70.4 |
|
|
28.2 |
nd |
28.7 |
37.8 |
38.0 |
39.5 |
44.4 |
43.8 |
||
| TB vs. LTBI vs. HC vs. other disease | Berry et al.[4] | 37.4 | nd | nd | nd | 27.6 | 18.7 | 28.5 | 37.2 |
Columns represent selected gene biomarker sets in the literature sets as well as in our dataset. Rows represent the studies on which the gene biomarker sets displayed in the columns were tested.
a = not determined.