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. Author manuscript; available in PMC: 2014 Mar 14.
Published in final edited form as: J Med Chem. 2013 Feb 20;56(5):2029–2037. doi: 10.1021/jm3016969

Table 3.

Activities of Compounds 19–29 against HIV-1 NL4-3 and NL4-3/V370A

Compound graphic file with name nihms-449471-t0023.jpg IC50a (μM) CC50b (μM)
NL4-3 NL4-3/V370A
19 7 graphic file with name nihms-449471-t0024.jpg 0.01 ± 0.004 (2) 2.6 ± 1.2 (2) >10
20 7 graphic file with name nihms-449471-t0025.jpg 0.01 ± 0.003 (2) 0.37 ± 0.15 (2) 7.9 ± 0.65 (2)
21 8 graphic file with name nihms-449471-t0026.jpg 0.03 ± 0.007 (3) 0.36 ± 0.13 (3) >10
22 8 graphic file with name nihms-449471-t0027.jpg 0.15 ± 0.05 (2) 0.33 ± 0.04 (2) >10
23 8 graphic file with name nihms-449471-t0028.jpg 0.02 ± 0.0072 (2) 0.92 ± 0.21 (2) >10
24 8 graphic file with name nihms-449471-t0029.jpg 0.03 ± 0.014 (2) 0.33 ± 0.25 (2) >10
25 8 graphic file with name nihms-449471-t0030.jpg 0.04 ± 0.018 (2) 0.95 ± 0.34 (2) >10
26 9 graphic file with name nihms-449471-t0031.jpg 0.02 ± 0.008 (2) 1.20 ± 0.13 (2) >10
27 9 graphic file with name nihms-449471-t0032.jpg 0.05 ± 0.016 (2) 1.58 ± 0.33 (2) >10
28 9 graphic file with name nihms-449471-t0033.jpg 0.02 ± 0.007 (2) 1.04 ± 0.42 (2) >10
29 9 graphic file with name nihms-449471-t0034.jpg 0.04 ± 0.019 (2) 0.34 ± 0.22 (2) 8.3± 0.56 (2)
a

C50: concentration that inhibited HIV-1 replication by 50%; presented as mean +/- SD.

b

CC50: concentration that reduced cell viability by 50%. IC50 and CC50 were determined by using CalcuSyn (Biosoft). The numbers in the parentheses represent the number of tests.