Table 1.
Ratio of peptidergic CTb-positive neurons* | |||||
---|---|---|---|---|---|
C5 | C6 | C7 | C8 | total | |
injury (n=4 rats) | 2/3 | 6/11 | 35/64 | 19/31 | 62/109 |
sham (n=5 rats) | 1/4 | 16/21 | 38/61 | 30/41 | 85/127 |
normal (n=4 rats) | 2/6 | 15/27 | 37/83 | 33/45 | 87/161 |
total (n=13 rats) | 5/13 | 37/59 | 110/208 | 82/117 | 234/397 |
Average % of peptidergic CTb-positive neurons* | |||||
C5 | C6 | C7 | C8 | total | |
injury (n=4 rats) | 66.7±57.7% | 45.0±33.2% | 56.2±18.4% | 61.1±13.0% | 56.4±9.4% |
sham (n=5 rats) | 25.0±35.4% | 78.4±25.5% | 59.8±14.7% | 69.4±43.3% | 66.9±18.3% |
normal (n=4 rats) | 41.7±52.0% | 47.8±32.6% | 45.9±12.6% | 75.1±19.8% | 53.1±13.7% |
total (n=13 rats) | 46.9±47.1% | 57.1±31.9% | 54.4±15.3%‡ | 68.6±28.3% | 59.4±14.8% |
Note: The denominator is the total number of CTb-positive neurons from all rats in each group for each DRG level; the numerator is the corresponding total number of neurons from all rats in each group that are positive for both CTb and CGRP. The percent values represent the average percent of CTb-positive neurons that are also CGRP-positive for each group and DRG level.
p=0.0084 compared to the percentage of CGRP-positive afferents of all neurons at C7.
CGRP, calcitonin gene-related peptide; CTb, cholera toxin subunit b.