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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: Curr Pathobiol Rep. 2013 Mar;1(1):43–52. doi: 10.1007/s40139-013-0008-9

Figure 1. MICRORNA ALTERATIONS IN HUMAN CANCERS AND THERAPEUTIC STRATEGIES.

Figure 1

MiRNA levels are altered in cancer. a | Amplification of oncogenic miRNAs results in decreased expression of target genes. b | Mutations can decrease the expression of tumor suppressive miRNAs or could potentiate the expression of oncogenic ones. c | Epigenetic changes such as promoter methylation, or trans-acting factors change the expression profile of miRNAs in a cell either decreasing or increasing their basal levels. d | Deletions eliminate the expression of tumor suppressive miRNAs increasing the expression of target genes.