Table 1.
Effects of supplementation with anacardic acids on the cellular profile of the bronchoalveolar lavage fluid in mice instilled with diesel exhaust particles.
Differential cells (×104) | Ctrl | DEP | DA50 | DA150 | DA250 |
---|---|---|---|---|---|
Total Cells | 5.88 ± 2.61 | 6.76 ± 2.05 | 8.10 ± 1.61 | 8.74 ± 1.42 | 7.52 ± 0.99 |
Eosinophils | 0.00 (0.00) | 0.00 (0.06) | 0.00 (0.02) | 0.00 (0.19) | 0.00 (0.00) |
Neutrophils | 0.04 (0.24) | 0.12 (0.13) | 0.21 (0.36) | 0.20 (0.31) | 0.23 (0.10)a |
Lymphocytes | 0.63 ± 0.42 | 0.47 ± 0.71 | 0.99 ± 0.56 | 1.33 ± 0.64a | 1.17 ± 0.80 |
Macrophages | 4.38 ± 2.24 | 5.36 ± 1.77 | 5.86 ± 1.06 | 6.33 ± 1.32 | 5.37 ± 0.73 |
Caliciform cells | 0.41 ± 0.26 | 0.47 ± 0.41 | 0.57 ± 0.36 | 0.19 ± 0.19 | 0.24 ± 0.19 |
Ciliary cells | 0.31 ± 0.27 | 0.26 ± 0.17 | 0.41 ± 0.20 | 0.54 ± 0.47 | 0.44 ± 0.27 |
Values are expressed as the means ± SD or as medians (interquartile range). a P < 0.05 significant difference compared to DEP. AAs: anacardic acids. Ctrl: control, animals received an intranasal instillation of 10 μL saline solution and were treated orally with 100 µL of cashew nut oil (CNO). DEP: diesel exhaust particles, intranasal instillation of 50 μg DEP/10 μL of saline and treated orally with 100 µL of CNO. DA50: intranasal instillation of 50 μg DEP/10 μL of saline and treated orally with 50 mg/kg of AAs. DA150: intranasal instillation of 50 μg DEP/10 μL of saline and treated orally with 150 mg/kg of AAs. DA250: intranasal instillation of 50 μg DEP/10 μL of saline and treated orally with 250 mg/kg of AAs.