Table 1.
Clinical data of all five patients with POF included into this study, which were documented at the Department of Obstetrics and Gynecology, University Medical Centre Ljubljana. All patients had increased serum levels of gonadotropins FSH (normal: <11.3 IU/L) and LH (normal: <11.6 IU/L) and thin endometrium.
| Clinical data | Patients | ||||
|---|---|---|---|---|---|
| P1 (R.A.) |
P2 (G.K.) |
P3 (M.S.) |
P4 (G.A.) |
P5 (P.R.A.) |
|
| Age (years) | 39 | 40 | 21 | 31 | 39 |
| FSH (IU/L) | 89.1 | 65.8 | 11.8 | 162.0 | 67.8 |
| LH (IU/L) | 23.3 | 23.4 | 10.1 | 59.0 | 37.8 |
| Prolactin (mg/L) | 12 | 4.6 | 16.4 | 9.3 | / |
| Estradiol (nmol/L) | <0.073 | 0.08 | 0.2 | / | / |
| Inhibin B (ng/L) | <10 | <10 | 52.4 | >10 | / |
| S-AMH (mg/L) | 0.00 | 0.00 | 0.89 | 0.00 | / |
| Karyotype | Abnormal (mosaic 45X, 47XXX, 48XXXX, 46XX) |
Normal (no FMR1-fragile X mutation) |
Normal (no FMR1-fragile X mutation) |
Normal (no FMR1-fragile X mutation) |
Normal (no FMR1-fragile X mutation) |
| Ovarian cortex histology | Inclusion cysts, corpora albicantia, focal ovarian surface epithelium, no follicles or oocytes | Inclusion cysts, corpora albicantia, simple or stratified ovarian surface epithelium, no follicles or oocytes | Simple columnar ovarian surface epithelium, several primordial follicles |
Simple cuboidal ovarian surface epithelium, corpus luteum in regression, no follicles or oocytes | Simple cuboidal ovarian surface epithelium, no follicles or oocytes |
| Antiovarian antibodies | No | No | Yes | Yes | No |
| Premature ovarian failure (POF) | Secondary (previous birth of a child), irregularities of menstrual cycles, thin endometrium | Primary (no children), irregular menstrual cycles, thin endometrium |
Primary (no children), irregular menstrual cycles, thin endometrium |
Primary (no children), amenorrhea, small left ovary, thin endometrium |
Secondary (pregnancy ended in spontaneous abortion), amenorrhea, thin endometrium |