Amino acid sequence alignment of copper-binding centers of MCBPs from remote phylogenetic lines.

Amino acids, forming the copper-binding mononuclear centers, are marked with black background. Amino acids, forming the copper-binding trinuclear centers, are marked with a bold font. Conservative glycine amino acids residues are marked with italic font. The GenPept sequence numbers are indicated in square brackets. Cp – ceruloplasmin; Heph – hephaestin, Heph1 – hefaestin-like protein; MCBP – multicopper blue protein; factor V – blood coagulation factor V; factor VIII – blood coagulation factor VIII; Fox1 и Fox2 – multicopper ferroxidase from Chlamydomonas reinhardtii; MnxG – Mn-oxidase.