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. Author manuscript; available in PMC: 2013 Mar 17.
Published in final edited form as: Annu Rev Physiol. 2011 Nov 4;74:299–323. doi: 10.1146/annurev-physiol-020911-153238

Figure 2.

Figure 2

Podocyte plasma membrane proteins and a canonical pattern of injury. Shown is an (incomplete) list of membrane proteins that have been implicated in the regulation of podocyte function in health and disease. Injured podocytes respond with a finite repertoire of changes, as depicted here. Our ability to repair the pathways initiated by the molecules on the podocyte plasma membrane to the precise cellular phenotypes listed here will provide not only novel insight but enormous opportunities for successful therapeutic interventions. Abbreviations: adiponectin R, adiponectin receptor; AT1R, angiotensin type 1 receptor; BKR, bradykinin receptor; CAR, Coxsackie and adenovirus receptor; CaSR, calcium-sensing receptor; CXCR/CCR, C-X-C/C-C chemokine receptor; FAT, protocadherin FAT1; Fc neo R, neonatal Fc receptor; FGFR, fibroblast growth factor receptor; FP, foot process; GBM, glomerular basement membrane; GHR, growth hormone receptor; GLEPP1, glomerular epithelial (podocyte) protein 1; IGFR, insulin growth factor receptor; insulin R, insulin receptor; MAC, membrane attack complex; Maxi-K, large-conductance calcium-activated potassium channel (also known as BK channel); mGluR, metabotropic glutamate receptor; NEP, neutral endopeptidase; RAGE, receptor for advanced glycation end products; SD, slit diaphragm; Sema3A, semaphorin-3A; TGF βR, transforming growth factor β receptor; TLR, Toll-like receptor; TRPC, transient receptor potential canonical; uPAR, urokinase receptor; VEGFR, vascular endothelial growth factor receptor.