An example of pathways at the intersection of AT1R and TRPC signaling at the plasma membrane as they converge on synaptopodin and Rho GTPase signaling in the cytosol to effect critical cytoskeletal remodeling. Dashed arrows indicate indirect effects between molecules. Abbreviations: TLR, Toll-like receptor; AT1R, angiotensin type 1 receptor; TRPC6/5, transient receptor potential canonical channels 6 and 5; CathL, cathepsin L; PKA/CamKII, protein kinase A/calcium-calmodulin-dependent protein kinase II; CnA, calcineurin; PI3K, phosphoinositide 3 kinase; Synpo, synaptopodin; MR, mineralocorticoid receptor; FP, foot process.