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. Author manuscript; available in PMC: 2013 Mar 17.
Published in final edited form as: Biol Psychiatry. 2013 Mar 1;73(5):393–395. doi: 10.1016/j.biopsych.2013.01.013

Figure 3.

Figure 3

Inflammatome gene regulatory (Bayesian) network enriched for AD genes identified and highly replicated in genetic studies. (A) A probabilistic causal network constructed from human omental adipose tissue collected in a cohort of morbidly obese patients (13). The nodes in the network are gene expression traits monitored in the omental adipose tissue from this cohort. The directed links between the nodes are derived via a Bayesian network reconstruction algorithm that leverages DNA variation as a systematic perturbation source to resolve causality (14). The pink nodes highlighted in this network are the inflammatome signature genes we have previously identified as strongly causally associated with a number of diseases (13–15). (B) A zoomed-in view of the subnetwork highlighted in panel (A) by the pink nodes. This inflammatome-based network is enriched for inflammatory and immune response gene ontology categories (color-coded pathways are indicated; all enrichments are significant at a 1% false discovery rate). In addition, genes previously identified in genetic studies and extensively replicated as associated with AD are represented in this network, including the genes highlighted: TREM2, CR1, CD33, MS4A4A, MS4A6A, and HCK