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. Author manuscript; available in PMC: 2013 Oct 12.
Published in final edited form as: Oncogene. 2012 Nov 19;32(41):4932–4940. doi: 10.1038/onc.2012.512

Figure 1.

Figure 1

PERK negatively regulates mTOR signaling in lactating mammary glands. (a, b) Immunohistochemical detection of p-AMPK and p-p70S6K on day 12 lactating mammary glands sections from control PERKloxP/loxP and mammary gland-specific PERK ko mice (PERKΔ/Δ). (a) Images showing enhanced p-AMPK staining in the control tissues along with strong staining in luminal cells and cell clusters (lower panels) that is reduced in PERKΔ/Δ tissues. (b) Images showing reduced p-p70S6K staining in PERKloxP/loxP control tissues in comparison with PERKΔ/Δ tissues.