Fig. 3. Effects of RTA 405 on basal arterial blood pressure in conscious rats.
Sprague Dawley rats were administered sesame oil or RTA 405 at a dose of 100 mg/kg body weight by oral gavage once daily for three consecutive days. Diastolic and systolic blood pressure was measured using tail cuff in conscious vehicle- and RTA 405-treated rats before treatment (D0) and 8 hours post-dose on Day 3 (D3). Fifteen rats in each group. Data are expressed as mean ± SD.