Fig. 7. Effect of RTA 405 on Ang II-induced Ca²⁺ response in human MCs.

A. Representative traces, showing [Ca²⁺]_i in response to 1 μM Ang II in MCs without treatment (UT) or treated with DMSO at 1:1000 dilution or RTA 405 at 100 nM for ~16 h, or with losartan at 5 μM for 5 min, or with PEG-catalase at 300 unit/ml for 30 min. [Ca²⁺]_B indicates the Ca²⁺ concentration in bathing solution. B. Summarized Ca²⁺ increases in response to Ang II from experiments presented in A. Δ[Ca²⁺]_i was calculated by subtracting [Ca²⁺]_i before application of Ang II from the peak [Ca²⁺]_i after application of Ang II. The numbers inside the parentheses represent the number of cells analyzed. * P<0.01, compared with both UT and DMSO groups.