. Author manuscript; available in PMC: 2014 Apr 30.

Published in final edited form as: Stat Med. 2012 Oct 15;32(9):1451–1466. doi: 10.1002/sim.5655

Table 3.

Simulation Scenarios

Parameters	High-Accu. Perfect-Trt	High-Accu. Imperfect-Trt	Low-Accu. Perfect-Trt High-Prev.	Low-Accu. Imperfect-Trt Low-Prev.

Sensitivity (test a)	0.95	0.95	0.85	0.85
Specificity (test a)	0.80	0.80	0.70	0.70
Sensitivity (test b)	0.90	0.90	0.80	0.80
Specificity (test b)	0.75	0.75	0.65	0.65
Prevalence	0.1	0.1	0.1	0.05
Resp. rate of Trt. I on D+	1.0	0.5	1.0	1.0
Resp. rate of Trt. I on D−	0.2	0.2	0.2	0.2
Resp. rate of Trt. II on D+	0.2	0.2	0.2	0.2
Resp. rate of Trt. II on D−	1.0	1.0	1.0	1.0
Range of f	[0.05,0.42]	[0.05,0.42]	[0.05,0.62]	[0.05,0.635]
R^A	0.852	0.8045	0.772	0.766
R^B	0.812	0.767	0.732	0.726
Δ₁	0.4	0.375	0.4	0.4