Table 2.
Difference in change in HAM-D symptoms (with 95% CI and effect size**) for chamomile versus placebo
| HAM-D Item | All Subjects (n=57) |
Co-morbid Depression (n=19) |
Past Depression (n=16) |
No Depression (n=22) |
|---|---|---|---|---|
| Depressed Mood (#1) | −0.13 (−0.44, 0.18) ES = 0.18 |
−0.09(−0.75, 0.58) ES = 0.11 |
−0.10 (−0.56, 0.35) ES = 0.19 |
−0.11 (−0.62,0.39) ES = 0.17 |
| Guilt (#2) | −0.55 (−0.85,−0.25)* ES = 0.72 |
−0.29 (−0.88, 0.29) ES = 0.36 |
−0.78(−1.36,−0.18)* ES = 1.08 |
−0.62(−1.03,−0.21)* ES = 1.07 |
| Suicide Ideation (#3) | −0.12 (−0.27, 0.03) ES = 0.26 |
−0.25 (−0.66, 0.16) ES = 0.35 |
−0.10 (−0.30, 0.11) ES = 0.33 |
−0.04 (−0.14, 0.06) ES = 0.33 |
| Insomnia early (#4) | 0.03 (−0.26, 0.32) ES = 0.04 |
0.21 (−0.34, 0.75) ES = 0.25 |
−0.70 (−1.29, −0.12)* ES = 0.86 |
0.49 (0.10, 0.88)* ES = 0.66 |
| Insomnia middle (#5) | −0.09 (−0.40, 0.21) ES = 0.12 |
−0.29 (−0.86, 0.28) ES = 0.41 |
0.27 (−0.34, 0.89) ES = 0.34 |
−0.33 (−0.77, 0.12) ES = 0.42 |
| Insomnia late (#6) | −0.53 (−0.86, −0.20)* ES = 0.69 |
−0.90 (−1.4, −0.41)* ES = 1.16 |
0.10 (−0.61, 0.80) ES = 0.12 |
−0.83(−1.32,−0.33)* ES = 1.10 |
| Work / Activities (#7) | −0.03 (−0.40, 0.30) ES = 0.04 |
−0.22 (−0.90, 0.47) ES = 0.24 |
−0.34 (−1.0, 0.36) ES = 0.46 |
0.32 (−0.21, 0.84) ES = 0.42 |
| Retardation (#8) | 0.02 (−0.14, 0.17) ES = 0.04 |
0.07 (−0.28, 0.43) ES = 0.15 |
−0.38 (−0.61, −0.15)* ES = 1.02 |
0.16 (−0.04, 0.37) ES = 0.60 |
| Agitation (#9) | 0.06 (−0.22, 0.34) ES = 0.09 |
−0.08 (−0.47, 0.31) ES = 0.12 |
0.12 (−0.40, 0.64) ES = 0.17 |
−0.19 (−0.64, 0.27) ES = 0.31 |
| Anxiety Psychic (#10) | −0.30 (−0.62, 0.01) ES = 0.42 |
−0.23 (−0.86, 0.40) ES = 0.31 |
−0.25 (−0.74, 0.25) ES = 0.40 |
−0.32 (−0.85, 0.21) ES = 0.43 |
| Anxiety Somatic (#11) | −0.07 (−0.36, 0.23) ES = 0.10 |
−0.39 (−0.95, 0.17) ES = 0.54 |
0.37 (−0.19, 0.93) ES = 0.50 |
−0.05 (−0.49, 0.38) ES = 0.08 |
| Gastrointestinal (#12) | −0.01 (−0.20, 0.19) ES = 0.01 |
0.03 (−0.44, 0.50) ES = 0.05 |
0.26 (0.02, 0.51)* ES = 0.71 |
−0.27(−0.52,−0.01)* ES = 0.70 |
| Somatic General (#13) | −0.32 (−0.59, −0.05)* ES = 0.52 |
−0.34 (−0.79, 0.11) ES = 0.53 |
−0.55 (−1.02, −0.09)* ES = 0.94 |
−0.10 (−0.58, 0.37) ES = 0.16 |
| Somatic Libido (#14) | −0.21 (−0.42, −0.002)* ES = 0.33 |
−0.53 (−0.94, −0.12)* ES = 0.72 |
−0.43 (−0.67, −0.20)* ES = 0.96 |
0.15 (−0.21, 0.51) ES = 0.22 |
| HAM-D Core (#1, #2, #3) |
−0.71 (−1.33, −0.10)* ES = 0.47 |
−0.25(−1.54, 1.04) ES = 0.14 |
−0.98 (−2.02, 0.06) ES = 0.78 |
−0.78 (−1.60, 0.03)† ES = 0.71 |
| HAM-D Total | −2.11 (−4.17, −0.06)* ES = 0.42 |
−3.74 (−7.7, 0.19)# ES = 0.65 |
−2.03 (−5.62, 1.56) ES = 0.47 |
−1.47 (−4.68, 1.73) ES = 0.32 |
*
(p<0.05)
#
(p=0.062)
†
(p=0.06)
**
Effect size = ES