Table 1.
IC50 values for the inhibition of cell viability in HSNCC, ESCC, and breast cancer cell lines by CACCinh-A01 in correlation with ANO1 amplification status
Cell line | Copy no. ANO1 | IC50 CaCCinh-A01 (µM) |
KYSE70 | n.a. | >20 |
KYSE150 | n.a. | >20 |
KYSE450 | n.a. | 16 |
Te1 | n.a. | 16 |
Te9 | n.a. | 17 |
FaDu | 14 | 8.5 |
Te11 | 9 | 2.9 |
MCF7 | n.a. | 20 |
Hs578t | n.a. | 20 |
BT549 | n.a. | 20 |
ZR75-1 | 3 | 8.0 |
HCC1954 | 3 | 8.0 |
MDA-MB-415 | 7 | 8.0 |
Data represent the mean of three independent experiments. n.a., not amplified.