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Proposed model for TPP riboswitch folding and ligand recognition. Gray area: Minimal aptamer motif that preorganizes into a Y-shaped platform (P1/P2/P4) in the presence of Mg2+. Dotted rectangle: Platform representing the conformation that is selected by the ligand TPP and thereby becomes further conformationally adapted. A high population with open forearms (P3, P5) and residual dynamics in the bound state are characteristic of this riboswitch.
