Fig. P1.

Analysis of organization in mutants with centrioles defects. (A) Comparison of B and C. (B) K-S statistical distance from populations of cc125 (WT), asq2 (mutant), and bld10 (mutant) cells to a population of cc124 cells (blue). (C) Same statistical distance measure applied to simulated versions of the four strains with randomly placed organelles. These simulated cells had the same parameters as the WT cells, but the locations of their organelles were drawn from a uniform random distribution within an ellipsoid. The real distance between the two WT populations, cc125 and cc124, is indistinguishable from statistically identical populations in the same cells. In contrast, both mutants (asq2 and bld10) are significantly distant from WT cc124, indicating a different underlying organizational distribution.