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Acute toxicity (LD50 values) and type of clinical signs induced by vipoxin, its components and reconstituted vipoxin.
| Compound tested | Route of admin. | LD50 (mg/kg) | LD50 (µmol/kg) | Type of clinical signs |
|---|---|---|---|---|
| Vipoxin | i.p. | 0.7-1.2 | 0.02–0.04 | neurotoxic |
| Vipoxin | i.v. | 0.9-1.3 | 0.03–0.04 | neurotoxic |
| PLA2 subunit | i.p. | 10–13 | 0.7–0.9 | not specified |
| PLA2 subunit | i.v. | 2.2-3.0 | 0.1–0.2 | not specified |
| Acidic component | i.p. | >30 | >2 | no signs |
| Reconstituted vipoxin (PLA2 + VAC, 1:1) | i.p. | 0.6-1.2 | 0.02–0.04 | neurotoxic |
