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. 2012 Dec;5(4):184–191. doi: 10.2478/v10102-012-0031-4

Table 2.

The lethal dose for the active ingredient of Neem tree (Azadirachtin).

Animal Route of Exposure LD50
Rat Oral >2 000 mg/kg bw
Rat Dermal >2 000 mg/kg bw
Rat Inhalation >2.11 mg/L
Rabbit, Ocular Mild irritant to conjunctiva
Guinea Pig Dermal Sensitisation Not a sensitiser