Table 2.
Effect of ceftriaxone plus sulbactam with VRP1034 on redox state and total thiol level in cadmium exposed group after 21 days of treatment.
| Groups | Plasma | Brain | Liver | Kidney | ||||
|---|---|---|---|---|---|---|---|---|
| GSH/GSSG | Total thiol | GSH/GSSG | Total thiol | GSH/GSSG | Total thiol | GSH/GSSG | Total thiol | |
| Control group | 4.88 | 4.33±0.98 | 8.89 | 121.4±10.85 | 9.03 | 145.36±10.88 | 4.81 | 75.12±4.52 |
| Cadmium exposed group | 1.5 | 1.57±0.34*** | 2.52 | 98.7±8.17*** | 2.97 | 124.21±11.20** | 2.63 | 46.89±5.87*** |
| Ceftriaxone plus sulbactam with VRP1034 treated group | 2.68 | 1.99±0.73ns | 6.19 | 104.3±10.21 | 5.19ns | 131.66±12.55ns | 3.98 | 60.24±6.54*** |
All data are Mean ± SD of eight animals of each group. The thiol level was expressed in the plasma (µmol/min/ml) whereas in the tissues (µmol/g tissue). Newman-Keuls test was performed for statistical significance between control group vs Cd exposed group and Cd exposed group vs ceftriaxone plus sulbactam with VRP1034 treated group.
***
Where p<0.001 (highly significant)
**
p<0.01(significant)
*
p<0.05 (significant)
Ns
p>0.05 (non significant).