Table 1.
Requirement of different transcription factors for lymphoid tissue and ILC development.
| Transcription factor | NK cells (ILC1) | Nuocytes/natural helper cells (ILC2) | LTi cells (NCR- ILC3) | NKp46+ ILCs (NCR+ ILC3) | Lymphoid tissue organogenesis |
|---|---|---|---|---|---|
| Id2 | - | - | - | - | None (Yokota et al., 1999) |
| RORγt | + | + | - | - | Still have NALT (Eberl et al., 2004) |
| RORα | + | - | + | + | Normal (Wong et al., 2012) |
| Nfil-3 (E4BP4) | - | + | + | + | Normal (Gascoyne et al., 2009) |
| Gata-3 | Lack thymic NK cells | - | + | + | Normal (Hoyler et al., 2012; Mjosberg et al., 2012) |
| AhR | + | ? | CD4- LTi cells reduced | Reduced | No ILFs and CP Normal PP and LN (Lee et al., 2011) |
| Tox | Fail to mature | ? | Reduced | Reduced | No LNs; reduced size and number PPs >90% reduced ILCs (Aliahmad et al., 2010) |
| Runx/Cbfβ2 | + | ? | Reduced | ? | Impaired organization Reduced (Tachibana et al., 2011) |
| T-bet | Immature | + | + | – | Normal |