Figure 5.

(A–D) Tumor growth patterns at t = 0, 20, 38, 46 h in response to glucose injection. Two cycles of proliferation-migration pattern are observed after initial (t = 0 h) and second (t = 26 h) injections of glucose (G = 10). Domain size = [0.2, 0.8] × [0.2, 0.8] ⊂ [0, 1]². (E) Glucose level at a cell site [cell id = 220; arrowhead in (A–D)]. (F) Time course of miR-451 activity and AMPK concentration at the cell site in (E). Dotted black line in the middle = threshold value of miR-451 (th_M). (G) Time course of cell populations: proliferative (blue square), migratory (red diamond), and total (black circle) cells. Some of proliferative cells become migratory ones around t = 16 h (black arrow) and t = 42 h (red arrow) when miR-451 levels drop below threshold due to lowered glucose levels. All migratory cells enter the proliferative phase around t = 26 (black arrowhead) in response to glucose injection.