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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: Exp Neurol. 2012 Dec 31;241:138–147. doi: 10.1016/j.expneurol.2012.12.013

Figure 2.

Figure 2

3H-dopamine uptake in HEK-hVMAT2 cells following exposure to DE-71 caused a dose-dependent inhibition of dopamine through VMAT2. Fractions of HEK-hVMAT2 cells were incubated with DE-71 or DMSO followed by incubation with 3H-dopamine. Resultant radioactive uptake into vesicles is shown as percent of vehicle treated control. Results demonstrate DE-71 inhibits dopamine uptake by VMAT2 with an IC50=2.8 μM.