Figure 1. Intracardiac injection of rAAV9 with SynI promoter leads to widespread gene transduction of neprilysin in the brain.
Brain sections from intact wild-type mice (a), intact neprilysin-deficient mice (b), and neprilysin-deficient mice 14 days after intracardiac injection of 4 × 1011 genome vectors of rAAV9-SynI::NEPWT (c) or rAAV9-SynI::NEPMT (d). Scale bars, 200 μm.