Skip to main content
. 2013 Mar 18;3:1472. doi: 10.1038/srep01472

Figure 3. Functional expression of NEP and Aβ levels in the limbic region after gene transfer.

Figure 3

(a) Levels of neprilysin-dependent endopeptidase activity in the limbic regions of intact wild-type, rAAV9-SynI::NEPMT- and rAAV-SynI::NEPWT-injected NEP-KO mice 14 days after intracardiac injection. Data represent mean ± s.e.m. of 7–9 mice. (b–d) Levels of Aβ40, Aβ42 and total Aβs in the limbic regions after the gene transfer were determined by sandwich ELISA. A non-specific reaction of the ELISA system was excluded by subtracting values obtained in the brain tissue from APP-KO mice. Data represent mean ± s.e.m. of 7–9 mice.