Table 3.
Summary of the effects of the different BIM compounds on GH secretion, food intake, and cFos activity in the ArcN, NTS, and AP after intraperitoneal administration in the mouse.
| Food intake | GH secretion | cfos ArcN | cfos AP | cfos NTS | cfos VMH | |
|---|---|---|---|---|---|---|
| Ghrelin | ± | +++ | ++ | +++ | +++ | = |
| 28131 | +++ | +++ | +++ | +++ | +++ | = |
| 28163 | ++ | = | ± | ± | +++ | = |
| Ghrelin + 28163 | No antagonistic action | Antagonistic action | No antagonistic action | No antagonistic action | No antagonistic action | = |
Food intake and cFos measured 90 min and GH 15 min post-injection.