Skip to main content
. 2013 Mar 18;4:23. doi: 10.3389/fendo.2013.00023

Table 1.

In vivo pharmacological effects of NPB/NPW.

Substance Effects Animal Preference
NPW (i.c.v.) Food intake ↑ Rat (male) Shimomura et al. (2002)
Body weight ↑ Tanaka et al. (2003)
NPW (i.c.v.) Body temperature ↑ Rat Mondal et al. (2003)
Heat production ↑
NPW ACTH ↑ Rat Hochol et al. (2007)
Estradiol ↑
NPW30 (i.c.v.) Arterial blood pressure (ABP) ↑ Rat Yu et al. (2007)
Heart rate (HR) ↑
Plasma catecholamine concentration ↑
NPB (i.c.v.) Food intake (light period–dark period) ↑ Mouse Tanaka et al. (2003)
NPB (i.c.v.) Prolactin ↑ Rat (male) Samson et al. (2004)
Growth hormone ↑
NPW23/NPB (i.t) Inflammatory pain ↓ Rat Yamamoto et al. (2005)
NPW/NPB (i.c.v.) Corticosterone in circulation ↑ Rat (male) Samson et al. (2004)
Taylor et al. (2005)
NPW/NPB (i.p) (Plasma level) parathyroid hormone ↑ Rat Hochol et al. (2007)
(Plasma level) corticosterone ↑
(Plasma level) testosterone ↑
NPW/NPB (i.c.v.) Circadian rhythm → Rat/mouse Our unpublished observations