Table 2.

Summary of behavioral phenotypes of NPBWR1 knockout mice (modified from Nagata-Kuroiwa et al., 2011).

Behavioral test	Parameter	Results
Open field test	Anxiety	Normal time spent in center of arena
Elevated plus maze test	Anxiety	Normal time spent and number of entries in open arms
Light-dark exploration test	Anxiety	Decrease in escape latency and time spent in light box
Porsolt forced swim test	Depression, learning helplessness	Normal time spent swimming
Prepulse inhibition test	Sensory motor reactivity	Normal percentage of prepulse inhibition
Marble burying behavior test	Compulsive behavior	Normal number of marbles buried
Cued and contextual fear conditioning test	Fear and memory	Decrease in time of freezing behavior during contextual testing while normal during auditory-cued testing
Morris water maze test	Spatial memory	Normal escape latency
Resident-intruder test	Social interaction	Abnormal social interaction (see text)
Stress-induced hyperthermia	Stress response	Exaggerated hyperthermia
Daily locomotor activity	Circadian rhythm	Normal in both light/dark cycle and constant dark condition. Normal entrainment by food or light
Sleep-wake behavior (EEG/EMG)	Sleep/wake cycle	Normal in each episode duration, times spent in each state in hourly sleep/wake analysis