| Self-reported questionnaire measures |
From pregnancy to 20 years postnatal; numbers with data vary from ∼5000 to
13 700; more than 9467 have completed at least 10 of the 18 questionnaires
to date.a
Demographics: Age, marital status, socio-economic position,
household composition, ethnicity, parity Personality: Questionnaire assessment of personality, attitudes,
behaviours, feelings about becoming pregnant and about becoming a
mother Life course characteristics: Retrospective report of their early
life exposures and characteristics, including birthweight, parental
occupations, childhood housing conditions Health-related behaviours: Smoking, alcohol, diet, physical
activity, illegal drug use Health:
○ Mental health (repeatedly assessed depression and
anxiety by using validated scales); ○ Reproductive health [repeatedly assessed
pregnancies (including their outcomes and pregnancy complications),
contraception, hormone replacement, menstrual patterns, cessation of
menstruation, hysterectomy/oophorectomy and in 2011 validated
questions for identification of those with polycystic ovary syndrome,
stress and urge incontinence] ○ Cardiometabolic health (repeatedly assessed
family history, own history of diagnosis of hypertension, diabetes,
high cholesterol, since 2010 Rose angina and peripheral vascular
disease questionnaires and questions about diagnoses of angina and
myocardial infarction and of experience of angioplasty or coronary
artery by-pass) ○ Musculoskeletal health [repeatedly assessed
diagnosis of arthritis (including type and joints affected), since
2008 asked about doctor diagnosis of osteoporosis, falls and
fractures] ○ Respiratory health (repeatedly asked about
diagnoses and symptoms of asthma and bronchitis) ○ Medication use (repeatedly asked to report about
names, dosage, frequency and reason of prescribed and over-the-counter
medication) ○ Childhood health (retrospective report of
hospital admissions, diagnoses, injuries and illnesses in
childhood) ○ Family health [retrospective report of whether
parents remain alive, age and cause of death if they had died, family
history of specific conditions (e.g. cardiovascular disease, diabetes,
cancer)]
|
| Obstetric data abstracted from medical records |
Available on 13 706 womena
Repeat measurements of weight [median (IQR) measurements per
woman: 12 (9–13)], blood pressure [median (IQR): 13 (11–16)],
protein- and glycos-uria [median (IQR): 12 (9–14)], peripheral oedema
[median (IQR): 13 (11–16)], haemoglobin [median (IQR): 3
(2–3)]. Derived (from repeat blood pressure and proteinuria measurements
and questionnaire data) hypertensive disorders of pregnancy (pre-existing
hypertension, gestational hypertension, pre-eclampsia, pre-clampsia
superimposed on pre-existing hypertension) Medical record recorded diagnoses of gestational diabetes, anaemia
and other complications of pregnancy Results of booking clinic blood tests—blood group,
haemoglobin, rubella immunity Whether amniocentesis or chorionic villus sampling was
undertaken Hospital admissions (whether or not any occurred on the total
sample; details of dates, length of stay and reason available on
8369) Results of ultrasound examinations (on 8369) Method and place of delivery Placental weight (available on 5769) Postnatal health (presence of anaemia on the total sample; details
of other conditions and treatments up to 14 days postnatal (or when were
discharged from care) available on 8369)
|
| Opportunistic clinic assessments |
Completed on mothers when they attended Focus assessments with their index child
and when staff and resources allowed these assessments; numbers and time points
vary and are detailed by each measure
Anthropometry: At 12–13 years postnatal: weight
(N = 439), standing height
(N = 439). At 15–16 years
postnatal: weight (N = 2412), standing
height (N = 2412), seated height
(N = 1635), waist
(N = 1638), hip
(N = 1637), arm
(N = 1641) and head
(N = 1641)
circumference Bioimpedance for percent body fat: At 12–13 years postnatal
(N = 439). At 15–16 years
postnatal (N = 2405) Dual-energy X-ray Absorptiomtry (DXA) whole body and hip scan for
fat, lean and bone mass: At 15–16 years postnatal
(N = 2086) Systolic and diastolic blood pressure and pulse rate: At
assessment 12–13 years postnatal
(N = 389). At 13–14 years
postnatal (N = 4173). At 15–16
postnatal (N = 3924) Emotional well-being and responses: Locus of Control at
12–13 years postnatal (N = 4069)
and at 15–16 years postnatal
(N = 4490). Development And Well-Being
Assessment (DAWBA) at 15–16 years postnatal
(N = 4242) Cognitive function: Theory Of Mind (TOM) assessment at 13–14
years postnatal (N = 4913). Wechsler
Abbreviated Scale of Intelligence (WASI) at 15–16 years postnatal
(N = 3900) Visual acuity and retinal photography at 15–16 years
postnatal (N = 1005)
|
| FoM1 follow-up clinic assessment |
Completed 2009–11, N = 4834a
Anthropometry: weight, height, waist, hip and head
circumference DXA whole body and hip scan for fat, lean and bone
mass Seated and standing systolic and diastolic blood pressure and
pulse rate Carotid intima-media thickness and arterial
stiffness Brief computer-completed questionnaire collecting information on
menstrual cycle (including date of last menstrual period), contraception,
use of hormone replacement, hysterectomy/oophorectomy, current use of any
medications (including dosage, frequency and reason),
allergies Fasting blood samples for storage and assays of haemoglobin,
glucose, insulin, pro-insulin, lipids, C-reactive protein, sex hormones and
for DNA in any women on whom a previous sample was not
available
|
| Funded and ongoing future FoM2–4 clinics |
These data will be collected on 3000 women who were pre- or peri-menopausal at
the time of FoM1 and likely to change through one or more of the stages of the
menopausal transition over the next 5 years; FoM2 began in August 2011 and to date
(February 2012) approximately 700 women have attended and completed the
assessments
Anthropometry: weight, height, waist, hip and head
circumference DXA whole body and hip scan for fat, lean and bone
mass Peripheral quantitative computer tomography of radius to assess
bone structure Seated and standing systolic and diastolic blood pressure and
pulse rate Cognitive function: logical memory test, backwards digital span,
spot the word test, digital symbol coding Physical capability: hand-grip strength, chair rise, balance and
3-m walk test Physical activity: accelerometer assessed Brief computer-completed questionnaire collecting information on
menstrual cycle (including date of last menstrual period), contraception,
use of hormone replacement, hysterectomy/oophorectomy, current use of any
medications (including dosage, frequency and reason),
allergies Fasting blood samples for storage and assays of haemoglobin,
glucose, insulin, pro-insulin, lipids, C-reactive protein, sex hormones and
for DNA in any women on whom a previous sample was not
available
|
| Record linkage |
All recruited women who provided permission have been linked to the National
Health Service (NHS) Central Register, which provides data on the following.
Death (including underlying and contributing causes and
date) Cancer (including type, site and date of registration (approximate
date of diagnosis) Emigration (out of the UK)
|
