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. Author manuscript; available in PMC: 2013 Mar 18.
Published in final edited form as: Gene. 2012 Dec 22;516(1):122–125. doi: 10.1016/j.gene.2012.12.055

Fig. 2.

Fig. 2

(A) Analysis of mutant flagSUR1 proteins. COSm6 cells were co-transfected with cDNAs for Kir6.2 and WT-flagSUR1, the M1394R-flagSUR1 or the E1323K-flagSUR1. Both mutants exhibit the lower core glycosylated band (solid arrow). However, neither mutant exhibits the upper complex glycosylated band (open arrow) as seen in WT, indicating that the mutant proteins are not processed and trafficked along the secretory pathway like the WT protein. (B) Both mutants show reduced cell surface expression, although the E1323K mutant retains some surface expression (16.98±4.87%; n=3).