Table 1.
| a. Baseline Demographic Data | ||||||
|---|---|---|---|---|---|---|
| Randomized Strata | Age | Gendera (%M) |
Educationa (years) |
Diagnosis | ||
| Scz/Scz Aff/Bipolar | Other | |||||
| AOQR | N | 55 | 55 | 52 | 21 | 34 |
| Mean or % | 64.1 | 60.00% | 13.3 | 38% | 62% | |
| Std. Deviation | 12.3 | na | 2.6 | na | na | |
| AQR | N | 19 | 19 | 19 | 8 | 11 |
| Mean or % | 60.3 | 73.70% | 14.5 | 42% | 58% | |
| Std. Deviation | 8.2 | na | 2 | na | na | |
| AOR | N | 38 | 38 | 36 | 16 | 22 |
| Mean or % | 69.4 | 63.20% | 10.6 | 42% | 58% | |
| Std. Deviation | 14.2 | Na | 5 | na | na | |
| AOQ | N | 18 | 18 | 15 | 7 | 11 |
| Mean or % | 63.9 | 66.70% | 14.2 | 39% | 61% | |
| Std. Deviation | 12.3 | na | 2.3 | na | na | |
| OQR | N | 17 | 17 | 17 | 3 | 14 |
| Mean or % | 68.7 | 94.10% | 12.5 | 18% | 82% | |
| Std. Deviation | 15.2 | na | 2 | na | na | |
| AR | N | 60 | 60 | 59 | 22 | 38 |
| Mean or % | 66.6 | 85% | 13.7 | 37% | 63% | |
| Std. Deviation | 13.4 | Na | 2.4 | na | na | |
| AQ | N | 25 | 25 | 24 | 15 | 10 |
| Mean or % | 64.7 | 52% | 13.4 | 60% | 40% | |
| Std. Deviation | 12.8 | na | 3.2 | na | na | |
| AO | N | 25 | 25 | 24 | 12 | 13 |
| Mean or % | 64.4 | 52.00% | 13.5 | 48% | 52% | |
| Std. Deviation | 12.3 | na | 2.4 | na | na | |
| QR | N | 16 | 16 | 16 | 6 | 10 |
| Mean or % | 67 | 75% | 13.4 | 38% | 63% | |
| Std. Deviation | 14 | Na | 2.9 | na | na | |
| OR | N | 26 | 26 | 25 | 10 | 16 |
| Mean or % | 70.7 | 65.40% | 12.6 | 38% | 62% | |
| Std. Deviation | 12.4 | na | 2.2 | na | na | |
| OQ | N | 33 | 33 | 32 | 8 | 25 |
| Mean or % | 70.6 | 60.60% | 13.8 | 24% | 76% | |
| Std. Deviation | 13.9 | na | 3.1 | na | na | |
| Total | N | 332 | 332 | 319 | 128 | 204 |
| Mean or % | 66.6 | 67.80% | 13.2 | 39% | 61% | |
| Std. Deviation | 13.1 | na | 3.1 | na | na | |
| b. Baseline Clinical Data | |||||
|---|---|---|---|---|---|
| Randomized Strata | BPRS Total | Waist Circumferencea (inches) |
Body Weighta (kg) |
Fasting Glucosea (mg/dL) |
|
| AOQR | N | 41 | 54 | 54 | 45 |
| Mean | 41.2 | 38.0 | 79.0 | 101.0 | |
| Std. Deviation | 11.3 | 6.3 | 20.6 | 26.4 | |
| AQR | N | 19 | 19 | 19 | 16 |
| Mean | 42.2 | 43.6 | 96.9 | 101.3 | |
| Std. Deviation | 8.3 | 7.5 | 25.5 | 17.0 | |
| AQR | N | 17 | 37 | 38 | 32 |
| Mean | 38.0 | 39.2 | 80.8 | 120.7 | |
| Std. Deviation | 7.8 | 5.2 | 24.4 | 71.3 | |
| AOQ | N | 12 | 14 | 16 | 13 |
| Mean | 37.4 | 43.8 | 97.4 | 106.4 | |
| Std. Deviation | 7.4 | 8.2 | 26.3 | 32.4 | |
| OQR | N | 12 | 15 | 16 | 16 |
| Mean | 38.4 | 40.0 | 84.4 | 104.3 | |
| Std. Deviation | 9.5 | 4.0 | 12.9 | 40.9 | |
| AR | N | 49 | 59 | 60 | 49 |
| Mean | 38.1 | 41.9 | 89.7 | 117.1 | |
| Std. Deviation | 10.6 | 5.6 | 18.3 | 44.0 | |
| AQ | N | 18 | 23 | 24 | 17 |
| Mean | 44.9 | 38.8 | 83.8 | 159.4 | |
| Std. Deviation | 10.1 | 6.9 | 22.1 | 120.6 | |
| AO | N | 19 | 24 | 25 | 20 |
| Mean | 43.7 | 38.9 | 81.3 | 102.8 | |
| Std. Deviation | 12.2 | 5.7 | 23.0 | 27.6 | |
| QR | N | 12 | 15 | 15 | 9 |
| Mean | 41.3 | 39.4 | 84.7 | 110.1 | |
| Std. Deviation | 13.0 | 4.6 | 19.2 | 50.4 | |
| OR | N | 18 | 25 | 26 | 24 |
| Mean | 35.4 | 38.4 | 76.7 | 104.4 | |
| Std. Deviation | 6.9 | 5.4 | 18.0 | 21.6 | |
| OQ | N | 21 | 31 | 32 | 24 |
| Mean | 40.7 | 39.0 | 80.4 | 98.5 | |
| Std. Deviation | 10.0 | 5.1 | 18.6 | 21.3 | |
| Total | N | 238 | 316 | 325 | 265 |
| Mean | 40.1 | 39.9 | 84.1 | 111.1 | |
| Std. Deviation | 10.3 | 6.1 | 21.4 | 50.4 | |
A = Aripiprazole
O = Olanzapine
Q = Quetiapine
R = Risperidone
Scz/Scz Aff = Schizophrenia / Schizoaffective disorders
na = not applicable
= There were significant differences among the strata groups on these variables.
1) Gender: Group difference: χ2=22.68, df = 10, p=0.012
Post-hoc pairwise significant differences: There were higher proportions of male patients in the strata OQR and AR than in a majority of other strata.
2) Education: Group difference: F=3.996, df =10,308, p < 0.001.
Post-hoc pairwise significant differences: AOR<AOQR, AQR, AOQ, AR, AQ, AO, and OQ.
A = Aripiprazole
O = Olanzapine
Q = Quetiapine
R = Risperidone
Scz/Scz Aff = Schizophrenia / Schizoaffective disorders
na = not applicable
= There were significant differences among the strata groups on these variables.
1) Waist Circumference: Group difference: F=3.089, df=10,315, p=0.001.
Post-hoc pairwise significant differences: AR stratum had higher waist circumference than all other strata.
2) Body Weight: Group difference: F=2.695, df=10,314, p=0.004)
Post-hoc pairwise significant differences: AR stratum had higher body weight than all other strata.
3) Fasting Glucose: Group difference: F=2.402, df=10,254, p=0.01.
Post-hoc pairwise significant differences: AQ>AOQR, AQR, AO, OQ, and OQ