. Author manuscript; available in PMC: 2013 Mar 18.

Published in final edited form as: Clin Pharmacol Ther. 2012 Mar 7;91(4):673–684. doi: 10.1038/clpt.2011.276

Table 2.

Efavirenz pharmacokinetic parameters

	First dose	Two weeks
CL/F (L/hr)	12.3 ± 6.1	20.1 ± 9.5^*
12 hr efavirenz/8-hydroxyefavirenz concentration ratio	152 ± 116	2.9 ± 2.5^*
8-hydroxyefavirenz apparent formation clearance (L/hr)	1.0 ± 0.6	10.7 ± 5.7^*

CL/F, apparent oral clearance of fexofenadine.

Significantly different from control (p<0.05)