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. Author manuscript; available in PMC: 2013 Mar 18.
Published in final edited form as: Clin Pharmacol Ther. 2012 Mar 7;91(4):673–684. doi: 10.1038/clpt.2011.276

Table 3.

Fexofenadine pharmacokinetics

Control Efavirenz
Cmax (ng/ml) 141 ± 56 118± 81
AUC0–∞ (ng •hr •ml−1) 716 ± 242 554 ± 302
AUC0–∞ ratio (efavirenz/control) 0.73 (0.59,0.91)
CL/F (ml•kg−1•min−1) 23.2 ± 12.6 33.2 ± 18.5*
Elimination t1/2 (hr) 5.4 ± 0.8 5.3 ± 0.8

Results are the arithmetic mean ± SD (n=12), except the AUC0–∞ ratio (efavirenz/control), which is the geometric mean (90% CI). AUC, area under the plasma concentration-time curve; Cmax, peak plasma concentration; CL/F, apparent oral clearance

*

Significantly different from control (p<0.05)